Considerations Brochure
Considering DAWNZERA? Read this brochure to learn about all the key ways that DAWNZERA could be right for you.
Resources
Resources to support your treatment journey
Explore informative materials designed to help you get to know DAWNZERA, plan with confidence, and take the next step with your doctor to start your new treatment journey!
Doctor Discussion Guide
Whether you’re considering your first long-term preventative treatment for HAE attacks or looking to evaluate if DAWNZERA is right for you, this guide can help you prepare for your next doctor’s visit.
Getting Started with DAWNZERA
How you get DAWNZERA might be different than what you are used to. Use this guide to help you understand the steps to getting started with DAWNZERA.
Test your disease control
If you're unsure whether your HAE is under control, the Angioedema Control Test (AECT) can help. The AECT is a 4-question test that can help you and your doctor determine if your angioedema is well controlled or poorly controlled.
FAQs
Have questions? Let’s get you answers!
You may have questions when starting or switching your hereditary angioedema (HAE) treatment. Here are answers to help you feel informed and supported every step of the way.
Treatment
How does DAWNZERA work?
DAWNZERA works differently by using RNA technology to prevent HAE attacks.
Learn more about How DAWNZERA works.
RNA=ribonucleic acid.
What are the possible side effects of DAWNZERA?
The most common side effects of DAWNZERA include injection-site reactions, upper respiratory tract infection, urinary tract infection, and abdominal discomfort.
These are not the only possible side effects of DAWNZERA. Tell your doctor if you have any side effect that bothers you or that does not go away while using DAWNZERA.
Learn more about safety and side effects.
Can I take other medications with DAWNZERA?
Tell your doctor about any other medications you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.
Where should I keep DAWNZERA once I receive it?
Store DAWNZERA in the refrigerator between 36 °F to 46 °F (2 °C to 8 °C) in the original carton.
If needed, DAWNZERA can be stored at room temperature up to 86 °F (30 °C) in the original carton for up to 6 weeks. If not used within 6 weeks stored at room temperature, throw away DAWNZERA.
Do not freeze.
Do not expose the autoinjector to heat.
Protect from direct light. Keep DAWNZERA and all medicines out of the reach of children.
Learn more about dosing and the autoinjector.
Insurance & Access
Will my insurance cover DAWNZERA?
Ionis Every Step™ will check to see what information your doctor will need to send to support the insurance coverage process for you.
To help with this process, make sure your doctor has your up-to-date insurance information and knows how you’re responding to your current treatment, including how many attacks you have been having, how intense they are, and how long they last. Your doctor will send this information with your prescription to Ionis Every Step. Reach out to your Patient Education Manager or Ionis Every Step with any other insurance questions you may have.
What if I don’t have insurance or my insurance plan doesn't cover DAWNZERA?
Ionis Every Step™ can help—a Case Manager can help you with potential financial assistance options for DAWNZERA. Call 1-844-444-4305, Monday to Friday, 8 AM to 8 PM ET, for more information.
What can I do if my insurance plan denies coverage for DAWNZERA?
Ionis Every Step™ will work with your doctor's office to ask your insurance plan to reconsider their decision. This includes reviewing the denial letter and collecting documentation from your doctor to submit for review. This is also known as the appeals process. If your doctor is unsure about submitting an appeal, you can call their office to share why this treatment matters to you. Let them know you’re interested in pursuing an appeal and ask if they’re able to help with the process.
I'm switching insurance plans. Will my new insurance plan cover DAWNZERA?
Our team at Ionis Every Step™ will work with you and your doctor to understand your new insurance plan’s coverage. Reach out to your Patient Education Manager once you have your new insurance plan information. Ionis Every Step will use your new insurance plan information to check your coverage for DAWNZERA. Don’t worry—our team will work with your doctor to send any additional information to your new insurance plan and reach out with financial assistance options that you may be eligible for if DAWNZERA is not covered.
How do I get DAWNZERA?
The Ionis Every Step™ Specialty Pharmacy will call to set up delivery of DAWNZERA right to your door. They will call from 1-844-444-4305. It may be helpful to save their phone number, so you know when they’re calling. DAWNZERA will not be shipped until you speak with the pharmacy about potential cost and to set up delivery.
Administration
When should I take DAWNZERA?
You, your care partner, or doctor should inject DAWNZERA once every 4 weeks or once every 8 weeks depending on your prescribed dosing frequency.
To learn how to take DAWNZERA, you can watch the How to use DAWNZERA video for step-by-step instructions or review the Instructions for Use.
How long do I hold the autoinjector after I hear the click?
Hold the autoinjector against the skin for 10 seconds to make sure the full dose has been given. Remove the autoinjector by lifting it straight up.
To learn how to take DAWNZERA, you can watch the How to use DAWNZERA video for step-by-step instructions or review the Instructions for Use.
What happens if I miss a dose?
If you miss a dose of DAWNZERA, administer the missed dose as soon as possible. Then inject DAWNZERA on the regular dosing schedule from the date of the most recently injected dose. Learn more about dosing and the autoinjector.
Continued support
What if my medication is lost or damaged?
If your medication wasn't delivered when you were expecting it or it arrives damaged, reach out to your Patient Education Manager* for next steps.
- Help you understand what happens next after your doctor prescribes DAWNZERA™ (donidalorsen), including an overview of the insurance process
- Answer your questions and provide educational resources about DAWNZERA or HAE
- Teach you how to use DAWNZERA in-person or virtually
- Connect you to additional Ionis Every Step members if you need more support
- Reach out to provide support throughout your treatment journey
*Patient Education Managers cannot give medical advice and do not replace your medical team. Contact your doctor for any medical concerns.
I'm going on vacation and need to get a refill early. What should I do?
You can work with the Ionis Every Step™ Specialty Pharmacy to set up your next delivery.
How can I get connected to a Patient Education Manager?
Once you sign up for Ionis Every Step™, you will be paired with your dedicated Patient Education Manager.† To sign up for Ionis Every Step and get connected with a Patient Education Manager, visit DAWNZERA.com/enroll or call 1-844-444-4305.
Learn more about Patient Education Managers.
†Patient Education Managers cannot give medical advice and do not replace your medical team. Contact your doctor for any medical concerns.
Who are the Ionis Every Step™ team members?
The Patient Education Manager‡ is your primary Ionis Every Step partner who can connect you with other Ionis Every Step team members if you need more support:
- Case Manager: Can help you understand your insurance coverage and find potential ways to save on DAWNZERA§
- Resource Navigator: Your guide for local social and emotional support
Meet the DAWNZERA Patient Education Managers.
†Patient Education Managers cannot give medical advice and do not replace your medical team. Contact your doctor for any medical concerns.
§Subject to program terms, conditions, and limits. Ionis Every Step consent is required for participation in all Ionis Every Step affordability programs.
Is there support to help me pay for DAWNZERA if I don’t have insurance?
If you don’t have insurance, Ionis Every Step can help you understand what financial assistance options may be available to help you get DAWNZERA. Find out which affordability program may be right for you by calling 1-844-444-4305, Monday to Friday, 8 AM to 8 PM ET.
How can I sign up for Ionis Every Step™ if I wasn’t able to sign the DAWNZERA Patient Enrollment and Prescription Form in my doctor’s office?
If you didn’t sign the form in your doctor’s office, you have other options to sign up for Ionis Every Step:
- Complete online
- Call Ionis Every Step at 1-844-444-4305, Monday to Friday, 8 AM to 8 PM ET
Key terms to know
Here are some words you may see or hear after your doctor prescribes DAWNZERA.
- Specialty pharmacy: A type of pharmacy that focuses on medications for complex conditions or that require specialty handling
- Exception: A request to get approval from an insurance plan before they will begin paying for a medication that they do not normally cover—this is typical for new medicines
- Prior authorization: A request to get approval from an insurance plan before they will begin paying for a medication
- Denial: An insurance plan’s decision to not pay for a medication
- Appeal: A request for an insurance plan to rethink a decision that denies a payment