in the study who used the Angioedema Control Test (AECT) reported being well-controlled after switching to DAWNZERA (exploratory endpoint interim analyses at Week 16 and Week 52).†
Switch safely
The only long-term preventative treatment for HAE attacks with a tested guide to support switching safely
The safety and efficacy of DAWNZERA were evaluated in the primary study. Across 6 months, those who took DAWNZERA every 4 weeks saw 81% fewer attacks on average vs placebo (primary endpoint). The most common side effects of DAWNZERA include injection-site reactions (such as redness or pain at the injection site), upper respiratory tract infection, urinary tract infection, and abdominal discomfort. Learn more about the safety of DAWNZERA.
In the open-label study, DAWNZERA was evaluated in people who switched from lanadelumab, berotralstat, or a C1-INH.
Across 1 year, people safely and successfully switched to DAWNZERA with no average loss of efficacy.
Hereditary angioedema (HAE) attack reduction was seen regardless of prior preventative treatment.*
of people surveyed in an interim analysis after 16 weeks of treatment preferred DAWNZERA over their previous preventative treatment, citing better disease control, less time required for treatment, and reduced injection pain as reasons for their preference.‡
These are not head-to-head data. Results are from an open-label, uncontrolled safety study in patients who wanted to switch to DAWNZERA, and was not powered for any comparisons between prior treatment groups; thus, these observations cannot be generalized to other patients on prior long-term preventative treatments.
C1-INH=C1-inhibitor.
*Previous on-treatment monthly HAE attack rate established in the 10-week screening period.
†The AECT is a simple, 4 question survey that helps you and your doctor understand how well your swelling symptoms have been managed over the past month.
‡More than 1 reason was permitted. Exploratory endpoint interim analysis at Week 16.
Hear from a person who switched to DAWNZERA
Actual DAWNZERA patients. Patients were compensated for their time.
NARRATOR: From DAWNZERA studios somewhere in North America, you’re watching The Reverse Roast with your host, Samaria…and special guests…Lindsey and Lauren!
DAWNZERA (donidalorsen) is a prescription medicine used to prevent hereditary angioedema (HAE) attacks in adults and children 12 years of age and older.
It is not known if DAWNZERA is safe and effective in children under 12 years of age.
This video is sponsored by Ionis Pharmaceuticals, Inc. The patients featured have been compensated for their participation.
Stay after the show for full Important Safety Information and please see full Prescribing Information and Patient Information for DAWNZERA at DAWNZERA.com.
Now, your host Samaria.
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SAMARIA: Hello! Hello! Hey, everybody. Welcome to The Reverse Roast and it’s me, your girl, Samaria. You might recognize me from the DAWNZERA Onboarding Video. I know, I know. I get stopped on the streets ALL, THE, TIME.
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SAMARIA: Let’s jump right in, today we have 2 absolute inspirations joining us. If you hang around an HAE Summit, you know them and you love them. Lindsey and Lauren! Roll the clip!
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LINDSEY: Hi, I’m Lindsey.
LAUREN: And I’m Lauren. We’re obviously twins.
LAUREN: HAE runs in our family, and we were diagnosed at a very young age. So we started swelling before we were even 2 years old.
LINDSEY: We knew what it was because our dad has HAE. They tested us at the same time, and then I had my first face swelling a couple of months later.
LAUREN: We missed a lot of school and social activities, as many as 20 to 30 days a quarter. Sometimes I think that's what's given me the work ethic that I have now because I was really upset if I got a B. I wanted to have straight A's.
LINDSEY: She would always get mad if I got better grades than her just so you know. While we were growing up, there were not many treatment options. Not until we were 15 were we able to take something, and we were just so desperate for something to slow our attacks.
LAUREN: Triggers can be any kind of things. They can be stress. You know, happy, wonderful, exciting moments–but a lot of times there wasn't a trigger at all.
LINDSEY: The unpredictability is real. We’ve done injections in some crazy places, including airport bathrooms more than once.
LINDSEY: Since DAWNZERA, I don't have to worry about canceling plans. I can go about my everyday life without it impacting me so greatly.
LAUREN: Things are very different for me on DAWNZERA. The day-to-day worry just is not running the show anymore. I can do all sorts of social activities, be involved in my work, and just all sorts of things I didn't know was possible.
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SAMARIA: Now let’s bring them out. Show some love for LINDSEY AND LAUREN! Alright. First of all, thank you both so much for being here and for sharing your story with us.
LINDSEY: Thanks. We're happy to be here.
LAUREN: Yes, very excited to be here.
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SAMARIA: Everyone here knows, far too well, that HAE is a journey. It starts with going to the doctor that very first time and finding out immediately that you have HAE. Because every allergist and doctor knows what HAE is, right? Yeah, we wish.
Another irritating thing about HAE is how hard it is to explain to people. It’s like forwarding a long email chain. Those who read from the beginning will get what you’re trying to tell them, but more likely, they’ll just email back asking a question that’s literally answered in the subject line.
Thankfully, modern HAE treatment has seen progress. Instead of just managing attacks, HAEA Guidelines says the goal of the HAE management plan is to live as normal a life as possible. That means skipping out on social events, not because of HAE, but because dinner reservations at 9 PM sound like more of a threat than an invitation.
So, HAE, if you're going to keep messing with people, you better think twice cause this community has had the kitchen sink thrown at them and they’ve still continued to come out the other end more powerful, educated, and resilient. They're not putting up with less than they deserve anymore!
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SAMARIA: Now, despite the, excuse my language, crud y’all have had to put up with, you have found ways to stay resilient. I don’t have to tell you, but I will, you both are champions. The way you have each other’s back through everything, really shows me that I could be a more supportive sister.
Hey, girl, sorry I didn’t text you back. I’ve been real busy! But I’m gonna call you right after this!
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SAMARIA: Alright. Now, let's shift to present day. You both are taking DAWNZERA now. What’s that been like?
LINDSEY: So, I can think about other things besides my HAE, and I am not allowing HAE to control my life.
SAMARIA: And let’s talk about dosing.
LINDSEY: So, I take my dose with a quick 10-second injection and it’s super-convenient with the autoinjector. And I’m living a good life. For me, my whole schedule used to revolve around swellings—work, social plans, everything. I can do the activities I love now.
SAMARIA: That is wonderful to hear. And Lauren, how about you?
LAUREN: Yeah, it’s the same for me. With DAWNZERA, I feel so happy and healthy. I feel genuinely great. We both love to travel, and so it's been great getting to travel without worrying about missing a dose or constant attacks. And even something as small as having access to a fridge to store the medicine.
SAMARIA: And how is it socially?
LINDSEY: Yeah, so we get to do a lot of the things we love now. So we go to the gym, we're involved in church, and I even started playing flute in our local orchestra. So for us, we're able to be present for our lives instead of managing HAE all the time.
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SAMARIA: I love catching up with you two, but we’re not done yet. I wanted to pass along some love from your friends and the rest of the team—they all had great things to say.
So, let’s reverse the roast…
(Flips the switch)
…it’s toast time!
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SAMARIA: You two have brought so much hope and meaning to the HAE community. With HAE being a rare disease, you two have worked overtime to educate others on the realities of living with it. Our team is honored to be able to work with both of you and hear your stories both on and off the stage.
As they say, if you want to know someone’s heart, look at their friends, and what they had to say about you two is a testament to how extraordinary you both are. Your friend, Kendalynne, told us, “I think Lindsey and Lauren’s younger selves would be so proud of the way they’ve supported each other. They have been each other’s biggest cheerleader, most loyal supporter through difficult seasons, and positive influence whatever the circumstance may be.”
Lindsey, that bright spirit of yours is what pushed you forward through stretches that no one should have to endure, and when we asked you what your younger self would be most proud of, you said, and I quote, “Dreaming outside my circumstances.” Chills. You’ve excelled in every definition of the word–from getting through school without medicine, graduating college, traveling the world, thriving professionally. You are A FORCE TO BE RECKONED WITH.
And Lauren, you’re a triple threat: MBA, world-traveler, and expert gift giver. We still get choked up thinking about when you secretly created a Facebook event and gave Lindsey a box of cards with encouraging messages from friends, doctors, people from the HAE community, and even her favorite author! You have a heart of gold. And I’m going to circle back to that MBA of yours. Because your dedication to getting your MBA during one of your hardest HAE years is truly inspiring AND she got a THREE. POINT. NINE. G.P.A., ladies and gentlemen–girl, you do not play around!
We spoke to y’all’s friend, Crystal, who we think says it best: “Lindsey and Lauren are some of the kindest and empathetic people I know. When they say it takes a village, it takes the right people, and these two women are top-tier leaders…Instead of dwelling on an invisible disease, they help spread awareness and positivity.”
When it comes to pushing the boundaries, Lindsey and Lauren are an absolute inspiration. You two help the HAE community see that “good enough” isn’t always good enough, and that asking for more is not only allowed, but necessary.
So, here’s to resilience, sisterhood, and speaking up. Give it up for Lindsey and Lauren—we can’t wait to see what comes next! |
SAMARIA: Now, let’s hear from both of you. Is there anything you'd like to say to the HAE community that's watching?
LAUREN: I would just say to envision what your life could be if HAE was not in total control of your life. Looking back, I'm not sure I ever thought this life I have right now was even possible. And also, with the encouragement of the HAE community and friends, they helped build me up to where I could dream of a future that was what I thought impossible at the time. So, I would say, just don't give up. And every HAE patient is different, and so just fight for the right treatment for yourself and for those around you.
LINDSEY: I would just say find your community. You need people that are going to build you up and support you. Don't settle for what's just okay with HAE. Strive for dreaming outside of HAE and how to make your life wonderful.
SAMARIA: You two are terrific.
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INDICATION DAWNZERA™ (donidalorsen) is a prescription medicine used to prevent hereditary angioedema (HAE) attacks in adults and children 12 years of age and older.
It is not known if DAWNZERA is safe and effective in children under 12 years of age.
IMPORTANT SAFETY INFORMATION Do not use DAWNZERA if you have had a serious allergic reaction, including anaphylaxis to donidalorsen or any of the ingredients in DAWNZERA.
Before using DAWNZERA, tell your healthcare provider about all of your medical conditions, including if you: are pregnant or plan to become pregnant, are breastfeeding or plan to breastfeed. It is not known if DAWNZERA can harm your unborn baby, or if it passes into your breast milk and if it can harm your baby.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of DAWNZERA? DAWNZERA can cause serious side effects including allergic reactions. Allergic reactions can include rash, trouble breathing, chest pain, fainting, dizziness, feeling lightheaded, swelling of the face, lips or tongue, and itching. Stop using DAWNZERA and call your healthcare provider or get emergency help right away if you have any of these symptoms.
The most common side effects of DAWNZERA include injection site reactions (such as redness or pain at the injection site), upper respiratory tract infection, urinary tract infection, abdominal discomfort.
These are not all the possible side effects of DAWNZERA. Tell your healthcare provider or treatment team about any side effects you may have.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call 1-800-FDA-1088.
Please see full Prescribing Information and Patient Information for DAWNZERA, also available at dawnzera.com.
DAWNZERA™ is a trademark of Ionis Pharmaceuticals, Inc. All other trademarks are the property of their respective owners. ©2026 Ionis Pharmaceuticals, Inc. US-DONI-2500178 v1.0 08/2026
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Lindsey: Okay, hold this.
SAMARIA: Oh my goodness. Rough, where? |
Dosing done differently
NO loading dose
Begin treatment with a single injection, right from the start
NO mixing or syringes
A convenient, single-use autoinjector§
NO daily medicine reminders
Dosing once every 4 weeks or every 8 weeks
§DAWNZERA autoinjectors can be stored in its original carton at room temperature (up to 86 °F [30 °C]) for up to 6 weeks. Do not expose your DAWNZERA autoinjector to heat, do not freeze it, and protect it from direct light.
Ready to switch to DAWNZERA?
Download the Doctor Discussion Guide to help start the conversation and to see if DAWNZERA may be right for you.
From helping you start to keeping you on track
Ionis Every Step connects you with a dedicated Patient Education Manager¶ right from the start to help guide you through your treatment journey—one step at a time.
¶Patient Education Managers cannot give medical advice and do not replace your medical team. Contact your doctor for any medical concerns.