Flip the switch™ on your expectations of hereditary angioedema (HAE) treatment.

in HAE attacks, with sustained results seen through 1 year in a long-term safety study

See the study results

with the only treatment backed by a clinical trial that evaluated how to safely switch*

Hear from a patient

As few as

with dosing every 4 or 8 weeks

Learn about dosing

C1-INH=C1-inhibitor.
*DAWNZERA was evaluated in people who switched from lanadelumab, berotralstat, or a C1-INH.

Join others living with HAE at a local educational event

Reserve your spot at an in-person or virtual event where you'll learn from a healthcare professional and a patient about DAWNZERA as a potential treatment option.

Your doctor has prescribed DAWNZERA. What’s next?

Ionis Every Step is here for you from your first step to every next step. Our dedicated team is focused on HAE—they can help you understand how to get your medicine, how to use it, and resources to help follow your doctor's treatment plan.

Get started

Test your disease control

The Angioedema Control Test (AECT) is a 4-question test that can help you and your doctor determine if you’re well controlled or poorly controlled.

Take the test

IMPORTANT SAFETY INFORMATION & INDICATION

Do not use DAWNZERA if you have had a serious allergic reaction, including anaphylaxis to donidalorsen or any of the ingredients in DAWNZERA.

Before using DAWNZERA, tell your healthcare provider about all of your medical conditions, including if you: are pregnant or plan to become pregnant, are breastfeeding or plan to breastfeed. It is not known if DAWNZERA can harm your unborn baby, or if it passes into your breast milk and if it can harm your baby.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of DAWNZERA?

DAWNZERA can cause serious side effects including allergic reactions. Allergic reactions can include rash, trouble breathing, chest pain, fainting, dizziness, feeling lightheaded, swelling of the face, lips or tongue, and itching. Stop using DAWNZERA and call your healthcare provider or get emergency help right away if you have any of these symptoms.

The most common side effects of DAWNZERA include injection site reactions (such as redness or pain at the injection site), upper respiratory tract infection, urinary tract infection, abdominal discomfort.

These are not all the possible side effects of DAWNZERA. Tell your healthcare provider or treatment team about any side effects you may have.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch, or call 1-800-FDA-1088.

INDICATION

DAWNZERA™ (donidalorsen) is a prescription medicine used to prevent hereditary angioedema (HAE) attacks in adults and children 12  years of age and older.

It is not known if DAWNZERA is safe and effective in children under 12 years of age.

Please see full Prescribing Information and Patient Information for DAWNZERA.